IWRS / RTSM

Randomisation and supply, on the same patient record as everything else.

Randomisation is a moment where several systems have to agree: the patient exists, is eligible, is consented on the current ICF, and a kit is available at their site. When those facts live in one platform, randomising is one action.

  • Randomisation
  • Kit allocation
  • IP accountability
  • Excursions
Study inventory · illustrative
78%
Kits available
Across 11 active sites
Kits on site
412
Dispensed
96
Quarantined · excursion
14
Expiring in 60 days
22
Sites below resupply level
2

One inventory, read by every role that touches it.

One inventory, many roles

Everyone who touches the supply chain, in one place with the right access.

Coordinating investigational product means six roles needing six different slices of the same information. Embedded in the platform, it is one inventory with access gated per role.

  • Central lab

    Shipments, receipts and sample logistics for its sites — without treatment assignment.

  • Clinical trial manager

    Inventory across every site, resupply triggers and excursions, before a site runs short.

  • CRA

    Reviews IP accountability at the visit, against the records the pharmacist entered.

  • Site pharmacist

    Receipt, storage, dispensing and returns, with excursions recorded on the affected kits.

  • Site nurse and coordinator

    Randomises and dispenses at the visit, on the same patient record as the eCRF.

  • Principal investigator

    Site accountability, and the permissioned, recorded route to unblind when necessary.

One randomisation

What one allocation sets in motion.

The patient is randomised once. Everything else is a consequence of the same record.

Patient 04-0044 randomisedarm B · kit B-1182
  • PatientsStatus moves to randomised
  • VisitsVisit windows calculated from day 0
  • SupplyKit B-1182 marked dispensed at Site 04
  • eCRFBaseline forms opened for the visit
  • AnalyticsEnrolment counters updated live
  • Audit trailAllocation recorded with actor and timestamp
What it covers

Allocation through accountability.

Randomisation

Simple, block and stratified schemes, configured per study.

Kit allocation

Kits assigned from site inventory at randomisation or dispensing.

Blinding control

Assignment visible only to entitled roles. Unblinding is permissioned and recorded.

Supply at site level

Inventory per site, resupplied on consumption rather than a fixed schedule.

Excursion handling

Affected kits quarantined and traced to shipment and to any patient dispensed.

IP accountability

Dispensed, returned and destroyed, reconciled per site and reviewed at the visit.

Common questions

IWRS, IRT, RTSM — what is the difference?

They largely describe the same system at different points in its history. IWRS (interactive web response system) replaced IVRS, the telephone version. IRT (interactive response technology) is the vendor-neutral term. RTSM (randomisation and trial supply management) describes what it does rather than how it is accessed, and is the term most sponsors now use. If you are comparing products, treat them as the same category.

Which randomisation methods are supported?

Simple, block and stratified randomisation, with block sizes and stratification factors configured per study. The allocation list is generated and held so that assignment is reproducible and auditable.

How is blinding maintained?

Treatment assignment is visible only to roles entitled to see it. Unblinding is a deliberate, permissioned action that is recorded with actor, timestamp and reason, and it is visible in the audit trail rather than being an untracked event.

Does it handle temperature excursions?

Excursions are recorded against the affected kits, which are quarantined until dispositioned. The kits remain traceable to the shipment they arrived in and to any patient they were dispensed to.

Demo

Bring your randomisation scheme.

30 minutes with a founder. We'll configure the scheme and the kit list, then randomise an illustrative patient and follow what it changes.